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【Webinar】Liquid Biopsy Detection of EGFR Mutations in NSCLC Patients Before and After Osimertinib Therapy

Liquid biopsy is a useful tool for longitudinal monitoring of non-small cell lung cancer (NSCLC) patients, but requires highly sensitive and reliable technologies for accurate detection of genomic alterations.

In this webinar, Evi Lianidou of the University of Athens will discuss a study that evaluated digital PCR (dPCR) for detecting EGFR mutations in plasma cell-free DNA (cfDNA) and corresponding circulating tumor cell (CTC)-derived genomic DNA (gDNA).


Topical :naica®Liquid Biopsy Detection of EGFR Mutations in NSCLC Patients Before and After Osimertinib Therapy

Date:June the 30th 2021

Time:8 AM PDT | 11 AM EDT | 4 PM BST | 5 PM CEST


The study used Stilla®’s Crystal Digital PCR™ in a group of EGFR-mutant NSCLC patients under osimertinib therapy at two time points: before treatment initiation and at progression of disease.

Dr. Lianidou will share how Crystal Digital PCR™ allowed her team to track tumor evolution through the detection of low-abundance mutations in cfDNA and CTCs predictive for treatment outcomes of NSCLC patients under osimertinib.

Dr. Lianidou will also discuss other highlights of the study, including:

▶ Crystal Digital PCR™ exhibited high concordance rates in correlation with Roche’s FDA-cleared Cobas technology;

▶ In some cases, Crystal Digital PCR™ was more sensitive than other methods in detecting the T790M mutation, which is the key resistance mutation found during treatment with first-line and second-line EGFR tyrosine kinase inhibitors;

▶ The presence of EGFR mutations in paired CTC-derived gDNA revealed discrepancies between CTCs and tumor or cfDNA genotyping.

Speakers’s Bio:Evi Lianidou, PhD

Professor of Analytical Chemistry, Clinical Chemistry & Head, Laboratory of Analytical Chemistry, ACTC Lab National and Kapodistrian University of Athens